Beta-Secretase: Structure, Function, and Evolution
نویسندگان
چکیده
منابع مشابه
Prediction of the tertiary structure of the beta-secretase zymogen.
beta-Secretase, also known as BACE, is a transmembrane aspartyl protease, which generates the N terminus of Alzheimer's disease amyloid beta-peptide. The activity of beta-secretase is the rate-limiting step of brain plaques production in vivo, and hence is a potential target for disease modifying drugs for Alzheimer's disease. To better understand the mechanism of action of beta-secretase and h...
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ژورنال
عنوان ژورنال: CNS & Neurological Disorders - Drug Targets
سال: 2008
ISSN: 1871-5273
DOI: 10.2174/187152708784936626